Motive & Goals

The “Molecular Pathway Discovery” is an open-source project divided in 4 pipelines:

• Best Cutoff Algorithm (BCA)

• Digital Pathway Curation (DPC)

• pseudo Pathway Modulation (pPMod)

• in silico Target Curation (isTC)

The goal of this project is to provide a set of tools to help researchers in molecular biology and systems biology curate pathways and suggest possible genes and molecular targets for drug discovery.

Pipelines

• Best Cutoff Algorithm (BCA)

  • Build the LFC-FDR landscape

  • Search for flexible cutoffs in high-throughput data

• Digital Pathway Curation (DPC)

  • Build the Ensemble Dataset

    • Calculates Gemini Reproducibility

    • Calculate One and Multi-Model Reproducibility

    • Find Gemini x PubMed agreements

  • Build the Multi-Source Dataset (MSD):

    • Calculates the Crowdsourcing Consensus

    • Calculate Gemini, PubMed, and Human accuracies

• pseudo Pathway Curation (PPC)

  • in development

• in silico Target Validation (isTV)

  • in development